Chromosomes are the cell's genetic content divided in structures formed by DNA and proteins, which contains several genes. The set of chromosomes in a cell is called karyotype, and the number of chromosomes for a species is characteristic. For example, in humans, the expected number of chromosomes is 46; in mice, the expected number of chromosomes is 40. When a cell has this expected number of chromosomes it is called euploid. When, for some reason, this number is different than the expected for the species, then the cell is called aneuploid.
The coordinator of Lance-RJ, Dr. Stevens Rehen, showed that a percentage of healthy and functional neural progenitor cells in the brain are aneuploid. Ever since, our group began to seek methods of cultivation that allow control of aneuploidy and neural differentiation in pluripotent stem cells. Our hypothesis is that the aneuploidy is compatible and necessary for neural differentiation. Thus, we evaluate the influence of various factors and conditions on the generation of neural-related aneuploidy, seeking ways to control chromosomal instability and efficient alternatives for neural induction in pluripotent stem cells.
Publications in chromosomal instability