Analysis of chromosomal instability in
pluripotent stem cells
The cell’s genetic content is divided into "packages", called
chromosomes. Chromosomes are structures formed by DNA and proteins, which
contains several genes. The set of chromosomes in a cell is called karyotype,
and the number of chromosomes for a species is characteristic. For example, in
humans, the expected number of chromosomes is 46; in mice, the expected number
of chromosomes is 40. When a cell has this expected number of chromosomes it is
called euploid. When, for some reason, this number is different than the
expected for the species, then the cell is called aneuploid.
The coordinator of
Lance-RJ, Dr. Stevens Rehen, showed that a percentage of healthy and functional
neural progenitor cells in the brain are aneuploid. Ever since, our group began
to seek methods of cultivation that allow control of aneuploidy and neural
differentiation in pluripotent stem cells. Our hypothesis is that the
aneuploidy is compatible and necessary for neural differentiation. Thus, we evaluate the influence of various factors
and conditions on the generation of neural-related aneuploidy, seeking ways to control
chromosomal instability and efficient alternatives for neural induction in
pluripotent stem cells.
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